一个新的 RING 扔进一个旧的 HAT。
A new RING tossed into an old HAT.
机构信息
Department of Biophysics and Biophysical Chemistry, Johns Hopkins University School of Medicine, Baltimore, MD 21205, USA.
出版信息
Structure. 2013 Sep 3;21(9):1479-81. doi: 10.1016/j.str.2013.08.011.
Abstract
p300 and CBP are multi-domain histone acetyltransferases (HATs) that regulate gene expression and are mutated in human diseases including cancer. Delvecchio and colleagues report the structure of the p300 catalytic core, revealing the presence of a previously unknown RING domain that regulates the enzyme's activity.
摘要
p300 和 CBP 是具有多个结构域的组蛋白乙酰转移酶（HATs），可调控基因表达，在包括癌症在内的人类疾病中发生突变。Delvecchio 及其同事报告了 p300 催化核心的结构，揭示了一个以前未知的 RING 结构域的存在，该结构域可调节该酶的活性。
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