Sun Ling, Li Wei Ran
Cleft Palate Craniofac J. 2013 Sep;50(5):535-41. doi: 10.1597/11-215.
Objective : To evaluate the skeletal maturation of girls with orofacial clefts using the cervical vertebral maturation method. Design : Case-control study. Setting : The School of Stomatology, Peking University. Patients : A total of 173 girls with cleft lip and/or palate from 8 to 16 years old were compared with 1038 age-matched girls without clefts. Results : In the 8- to 9-year-olds, most of the girls from both groups were in cervical stage 1. In the 14- to 15-year-olds and 15- to 16-year-olds, almost all the girls from both groups were in cervical stages 5 and 6, and most of the 15- to 16-year-old girls were in cervical stage 6. Differences existed in each year for 9- to 14-year-olds, which was confirmed by statistical analysis. After ordinal logistical regression of data from girls 9 to 14 years of age, girls of the same age in the non-cleft lip and/or palate group were associated with 1.559 times the odds of having achieved higher cervical stages than those in the cleft lip and/or palate group. Most girls without cleft lip and/or palate were in cervical stages 3 and 4 in the 11- to 12-year-olds; whereas, it was not so obvious in the girls with cleft lip and/or palate. By the age of 12, girls with cleft lip and/or palate had 2.667 times the risk of delayed cervical stage 3, and the 95% confidence interval for the odds ratio was 1.013 to 7.019. Conclusions : Girls with cleft lip and/or palate are at a higher risk of delayed pubertal growth.
采用颈椎成熟度法评估唇腭裂女童的骨骼成熟情况。设计：病例对照研究。地点：北京大学口腔医学院。患者：共173名8至16岁的唇裂和/或腭裂女童与1038名年龄匹配的非唇腭裂女童进行比较。结果：在8至9岁的女童中，两组中的大多数女童处于颈椎1期。在14至15岁以及15至16岁的女童中，两组中几乎所有女童都处于颈椎5期和6期，且15至16岁的大多数女童处于颈椎6期。9至14岁各年龄段均存在差异，经统计分析得到证实。对9至14岁女童的数据进行有序逻辑回归后，非唇裂和/或腭裂组中同年龄女童达到较高颈椎分期的几率是唇裂和/或腭裂组女童的1.559倍。在11至12岁时，大多数非唇裂和/或腭裂女童处于颈椎3期和4期；而唇裂和/或腭裂女童中情况并非如此明显。到12岁时，唇裂和/或腭裂女童出现颈椎3期延迟的风险是2.667倍，优势比的95%置信区间为1.013至7.019。结论：唇裂和/或腭裂女童青春期生长延迟的风险更高。
