亚洲印度裔格雷夫斯病患者的人类白细胞抗原

HLA antigens in Asian Indian patients with Graves' disease.

作者信息

Tandon N, Mehra N K, Taneja V, Vaidya M C, Kochupillai N

机构信息

Department of Endocrinology, All-India Institute of Medical Sciences, New Delhi.

出版信息

Clin Endocrinol (Oxf). 1990 Jul;33(1):21-6. doi: 10.1111/j.1365-2265.1990.tb00461.x.

DOI:10.1111/j.1365-2265.1990.tb00461.x

PMID:2401095

Abstract

A study of 57 Asian Indian patients with Graves' disease revealed a significant increase in the frequency of HLA-DQW2 (61.4%) as compared to the control population (22.6%) giving a relative risk of 5.4. Less prominent but statistically significant increase in the frequency of HLA-A10 (29.8% patients as opposed to 10.5% controls) and HLA-B8 (28.1% patients as opposed to 8.7% controls) was also observed. Further, patients carrying the phenotypes HLA-A10 and HLA-B8 were more prone to develop the disease at a younger age. Two HLA haplotypes, namely A10-B8 and B8-DR3, were found in significant linkage disequilibrium in our patients with Graves' disease. Patients carrying these haplotypes also had a tendency to develop the disease at an earlier age.

摘要

一项针对57名亚洲印度裔格雷夫斯病患者的研究显示，与对照组人群（22.6%）相比，HLA-DQW2的频率显著增加（61.4%），相对风险为5.4。还观察到HLA-A10（患者中为29.8%，而对照组为10.5%）和HLA-B8（患者中为28.1%，而对照组为8.7%）的频率有不太显著但具有统计学意义的增加。此外，携带HLA-A10和HLA-B8表型的患者更容易在年轻时发病。在我们的格雷夫斯病患者中，发现两种HLA单倍型，即A10-B8和B8-DR3，存在显著的连锁不平衡。携带这些单倍型的患者也倾向于在更早的年龄发病。