Associate Professor, Department of Cariology, Restorative Sciences and Endodontics, University of Michigan School of Dentistry, 1011 N University, Ann Arbor, MI 48109, USA.
J Evid Based Dent Pract. 2013 Sep;13(3):97-9. doi: 10.1016/j.jebdp.2013.07.004.
Results from the xylitol for adult caries trial (X-ACT). Bader JD, Vollmer WM, Shugars DA, Gilbert GH, Amaechi BT, Brown JP, Laws RL, Kunkhouser KA, Makhija SK, Ritter AV, Leo MC. JADA 2013; 144(1): 21-30.
Margherita Fontana, DDS, PhD, Carlos Gonzalez-Cabezas, DDS, MSD, PhD PURPOSE/QUESTION: Among an adult population at risk of dental caries, does the use of five 1 g xylitol lozenges per day over 33 months reduce the experience of cavitated caries lesions?
Government: National Institute of Dental and Craniofacial Research
TYPE OF STUDY/DESIGN: Multicenter, double blind, placebo-controlled, randomized clinical trial
Level 1: Good quality, patient-oriented evidence
B: Limited quality patient-oriented evidence.
木糖醇治疗成人龋齿试验（X-ACT）的结果。Bader JD, Vollmer WM, Shugars DA, Gilbert GH, Amaechi BT, Brown JP, Laws RL, Kunkhouser KA, Makhija SK, Ritter AV, Leo MC. JADA 2013; 144(1): 21-30.
Margherita Fontana, DDS, PhD, Carlos Gonzalez-Cabezas, DDS, MSD, PhD
目的/问题：在有发生龋齿风险的成年人群中，每天使用五片 1 克木糖醇锭是否能减少 33 个月后发生的龋齿病变？
政府：美国国立牙科和颅面研究所
研究类型/设计：多中心、双盲、安慰剂对照、随机临床试验
1 级：高质量、以患者为中心的证据
B：有限质量的以患者为中心的证据。
