Gungor Sule, Kamali Gulcin, Canat Dilek, Gokdemir Gonca
Okmeydani Training and Research Hospital, Istanbul, Turkey.
Dermatol Online J. 2013 May 15;19(5):18176.
A chondroma is a benign, slow-growing cartilaginous tumor. When arising in the medullary cavity of a bone it is referred to as an enchondroma-a very common bone tumor. When occurring in soft tissue without any connection to bone, which is extremely rare, it is known as a soft-tissue chondroma (STC). A 38-year-old female presented with a 2- year history of right index finger pulp swelling in the absence of trauma. On physical examination a firm, immobile nodule, approximately 1 cm in diameter, was observed on the palmar side of the right index finger. The overlying skin was normal. Plain X-ray showed a dense, soft tissue shadow without calcification in the right index finger pulp, but the adjacent bones were intact. MRI showed a 1-cm diameter, well-demarcated lesion with intermediate signal intensity on T1-weighted images and high signal intensity on T2-weighted images. MRI also showed that the tumor had no bony involvement and that the adjacent bones were normal. Histopathological examination of the biopsy specimen showed lobules of mature hyaline cartilage with chondrocytes in the lacunae in the dermal and subdermal layers. Mitotic figures and an increase in cellular atypism were not observed. Based on the histopathological and radiological findings, the mass was thought to be an STC and total excision was performed. Examination of the excised mass confirmed the diagnosis of STC. STC should be considered in patients with a slowly growing, mildly painful cutaneous mass.
软骨瘤是一种良性、生长缓慢的软骨肿瘤。当它起源于骨髓腔时,被称为内生软骨瘤——一种非常常见的骨肿瘤。当发生在与骨无任何连接的软组织中时(极为罕见),它被称为软组织软骨瘤(STC)。一名38岁女性,在无外伤史的情况下,右手示指指腹肿胀2年。体格检查发现右手示指掌侧有一个质地坚硬、固定不动的结节,直径约1cm。其上覆盖的皮肤正常。X线平片显示右手示指指腹有一个致密的软组织阴影,无钙化,但相邻骨骼完整。MRI显示一个直径1cm、边界清晰的病灶,在T1加权像上呈中等信号强度,在T2加权像上呈高信号强度。MRI还显示该肿瘤未累及骨骼,相邻骨骼正常。活检标本的组织病理学检查显示,在真皮和皮下层有成熟透明软骨小叶,软骨细胞位于陷窝内。未观察到有丝分裂象和细胞异型性增加。根据组织病理学和影像学检查结果,该肿块被认为是STC,并进行了完整切除。对切除的肿块进行检查证实了STC的诊断。对于有缓慢生长、轻度疼痛的皮肤肿块的患者,应考虑STC的可能。