Biology Department, Johns Hopkins University, Baltimore, MD 21218, USA.
Curr Opin Virol. 2013 Dec;3(6):664-9. doi: 10.1016/j.coviro.2013.08.008. Epub 2013 Sep 4.
Avian retroviruses were originally identified as cancer-inducting filterable agents in chicken neoplasms at the beginning of the 20th century. Since their discovery, the study of these simple retroviruses has contributed greatly to our understanding of viral replication and cancer. Avian retroviruses continue to evolve and have great economic importance in the poultry industry worldwide. The aim of this review is to provide a broad overview of the genome, pathology, and replication of avian retroviruses. Notable gaps in our current knowledge are highlighted, and areas where avian retroviruses differ from other retroviruses are emphasized.
禽类逆转录病毒最初在 20 世纪初被确定为鸡肿瘤中诱导癌症的可过滤因子。自发现以来,这些简单的逆转录病毒的研究极大地促进了我们对病毒复制和癌症的理解。禽类逆转录病毒不断进化,在全球家禽业中具有重要的经济意义。本综述的目的是提供对禽类逆转录病毒的基因组、病理学和复制的广泛概述。突出显示了我们当前知识中的明显差距,并强调了禽类逆转录病毒与其他逆转录病毒的不同之处。