超越樱桃红斑：鞘脂类介导的神经退行性和炎症性疾病的眼部表现。
Beyond the cherry-red spot: Ocular manifestations of sphingolipid-mediated neurodegenerative and inflammatory disorders.
机构信息
Department of Ophthalmology, University of Oklahoma Health Sciences Center (OUHSC), Oklahoma City, Oklahoma, USA.
Dean A. McGee Eye Institute, Oklahoma City, Oklahoma, USA.
出版信息
Surv Ophthalmol. 2014 Jan-Feb;59(1):64-76. doi: 10.1016/j.survophthal.2013.02.005. Epub 2013 Sep 5.
Abstract
Sphingolipids are a ubiquitous membrane lipid present in every cell and found most abundantly in neural tissues. Disorders such as Tay-Sachs or Niemann-Pick disease are the most familiar examples of dysfunction in sphingolipid metabolism and are typically associated with neurodegeneration and ocular findings such as blindness. More recently, the role of bioactive sphingolipids has been established in a multitude of cellular events, including cell survival, growth, senescence and apoptosis, inflammation, and neovascularization. We discuss our current knowledge and understanding of sphingolipid metabolism and signaling in the pathogenesis of ocular diseases.
摘要
鞘脂类是一种普遍存在于每个细胞的膜脂质，在神经组织中含量最丰富。诸如泰萨二氏症或尼曼-皮克病等疾病是鞘脂代谢功能障碍的最常见例子，通常与神经退行性变和眼部表现如失明有关。最近，生物活性鞘脂在多种细胞事件中发挥了作用，包括细胞存活、生长、衰老和凋亡、炎症和新生血管形成。我们讨论了我们目前对鞘脂代谢和信号转导在眼部疾病发病机制中的认识。
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