Howard Hughes Medical Institute, Department of Immunobiology, Yale University School of Medicine, New Haven, CT 06520, USA.
Trends Immunol. 2013 Oct;34(10):487-94. doi: 10.1016/j.it.2013.08.001. Epub 2013 Sep 3.
Genital herpes is an incurable, chronic disease that affects millions of people worldwide. Not only does genital herpes cause painful, recurrent symptoms, it is also a significant risk factor for the acquisition of other sexually transmitted infections such as HIV-1. Antiviral drugs are used to treat herpes simplex virus (HSV) infection, but they cannot stop viral shedding and transmission. Thus, developing a vaccine that can prevent or clear infection will be crucial in limiting the spread of disease. In this review we outline recent studies that improve our understanding of host responses against HSV infection, discuss past clinical vaccine trials, and highlight new strategies for vaccine design against genital herpes.
生殖器疱疹是一种无法治愈的慢性疾病,影响着全球数百万人。生殖器疱疹不仅会导致疼痛、反复发作的症状,还是感染其他性传播感染(如 HIV-1)的重要危险因素。抗病毒药物用于治疗单纯疱疹病毒(HSV)感染,但它们不能阻止病毒脱落和传播。因此,开发一种能够预防或清除感染的疫苗对于限制疾病传播至关重要。在这篇综述中,我们概述了最近的研究,这些研究增进了我们对宿主针对 HSV 感染的反应的理解,讨论了过去的临床疫苗试验,并强调了针对生殖器疱疹的疫苗设计的新策略。