University of Cincinnati, Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USA.
Antiviral Res. 2020 Aug;180:104821. doi: 10.1016/j.antiviral.2020.104821. Epub 2020 Jun 13.
Herpes simplex virus (HSV) infections type 1 (HSV-1) and type 2 (HSV-2) are common throughout the world. Infections are lifelong and may produce both acute and recurrent vesiculoulcerative disease as well as more severe diseases. Despite disappointing results from recent HSV vaccine trials new vaccines and more potent antiviral therapies continue to be developed. These newer approaches require initial evaluations in animal models. In this review I have briefly described some of the models available and then more thoroughly describe the guinea pig model of acute and recurrent genital herpes infections. As discussed, the guinea pig model most closely mimics human disease and provides several important endpoints for evaluating vaccines and antivirals.
单纯疱疹病毒（HSV）感染 1 型（HSV-1）和 2 型（HSV-2）在全球范围内很常见。感染是终身的，可能会导致急性和复发性水疱溃疡性疾病以及更严重的疾病。尽管最近 HSV 疫苗试验的结果令人失望，但新的疫苗和更有效的抗病毒疗法仍在不断开发中。这些新方法需要在动物模型中进行初步评估。在这篇综述中，我简要描述了一些现有的模型，然后更详细地描述了急性和复发性生殖器疱疹感染的豚鼠模型。如前所述，豚鼠模型最能模拟人类疾病，并为评估疫苗和抗病毒药物提供了几个重要的终点。
