血清钾水平与心房颤动风险：鹿特丹研究。

Serum potassium levels and the risk of atrial fibrillation: the Rotterdam Study.

机构信息

Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Netherlands Consortium for Healthy Aging (NCHA), The Netherlands.

出版信息

Int J Cardiol. 2013 Oct 15;168(6):5411-5. doi: 10.1016/j.ijcard.2013.08.048. Epub 2013 Aug 24.

DOI:10.1016/j.ijcard.2013.08.048

PMID:24012173

Abstract

BACKGROUND

Atrial fibrillation is the most common sustained arrhythmia in the elderly. Serum potassium is associated with ventricular arrhythmias and cardiac arrest. Little is known about the association of serum potassium with atrial fibrillation. The objective of this study was to investigate the association of serum potassium and the risk of atrial fibrillation in a population based setting.

METHODS

The study was performed within the prospective population-based Rotterdam Study. The study population consisted of 4059 participants without atrial fibrillation at baseline for whom baseline levels of serum potassium were measured. Atrial fibrillation was ascertained from centre visit ECG assessments as well as medical records.

RESULTS

During a mean follow up of 11.8 years (SD=5.2 yr), 474 participants developed atrial fibrillation. Participants with hypokalemia (<3.5 mmol/l) had a higher risk of atrial fibrillation (HR: 1.63, 95%CI: 1.03-2.56) than those with normokalemia (3.5-5.0 mmol/l). This association was independent of age, sex, serum magnesium, and other potential confounders. Especially in participants with a history of myocardial infarction, those with hypokalemia had a higher risk of atrial fibrillation than those with normokalemia (HR: 3.81, 95%-CI: 1.51-9.61).

CONCLUSIONS

In this study low serum levels of potassium were associated with a higher risk of atrial fibrillation.

摘要

背景

房颤是老年人中最常见的持续性心律失常。血清钾与室性心律失常和心脏骤停有关。关于血清钾与房颤的关系知之甚少。本研究旨在探讨人群中血清钾与房颤风险的关系。

方法

该研究在前瞻性人群基础的鹿特丹研究中进行。研究人群包括 4059 名基线时无房颤的参与者，他们的基线血清钾水平得到了测量。房颤是通过中心就诊的心电图评估和医疗记录来确定的。

结果

在平均 11.8 年（SD=5.2 年）的随访期间，474 名参与者发生了房颤。低钾血症（<3.5mmol/L）患者发生房颤的风险高于正常血钾（3.5-5.0mmol/L）患者（HR：1.63，95%CI：1.03-2.56）。这种关联独立于年龄、性别、血清镁和其他潜在的混杂因素。特别是在有心肌梗死史的患者中，低钾血症患者发生房颤的风险高于正常血钾患者（HR：3.81，95%-CI：1.51-9.61）。