精神分裂症和精神病性双相情感障碍患者的颞上回和颞中回的形态测量学研究。
Morphometry of superior temporal gyrus and planum temporale in schizophrenia and psychotic bipolar disorder.
机构信息
Center for Imaging Science, Johns Hopkins University, Baltimore, MD 21218, USA; Institute for Computational Medicine, Johns Hopkins University, Baltimore, MD 21218, USA; Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD 21218, USA.
出版信息
Schizophr Res. 2013 Nov;150(2-3):476-83. doi: 10.1016/j.schres.2013.08.014. Epub 2013 Sep 6.
Structural abnormalities in temporal lobe, including the superior temporal gyrus (STG) and planum temporale (PT), have been reported in schizophrenia (SCZ) and bipolar disorder (BPD) patients. While most MRI studies have suggested gray matter volume and surface area reduction in temporal lobe regions, few have explored changes in laminar thickness in PT and STG in SCZ and BPD. ROI subvolumes of the STG from 94 subjects were used to yield gray matter volume, gray/white surface area and laminar thickness for STG and PT cortical regions. Morphometric analysis suggests that there may be gender and laterality effects on the size and shape of the PT in BPD (n=36) and SCZ (n=31) with reduced laterality in PT in subjects with SCZ but not in BPD. In addition, PT surface area was seen to be larger in males, and asymmetry in PT surface area was larger in BPD. Subjects with SCZ had reduced thickness and smaller asymmetry in PT volume. Thus, the PT probably plays a more sensitive role than the STG in structural abnormalities seen in SCZ.
颞叶结构异常，包括颞上回（STG）和颞平面（PT），在精神分裂症（SCZ）和双相情感障碍（BPD）患者中已有报道。虽然大多数 MRI 研究表明颞叶区域的灰质体积和表面积减少，但很少有研究探索 SCZ 和 BPD 中 PT 和 STG 层厚度的变化。使用 94 名受试者的 STG ROI 子体积来获得 STG 和 PT 皮质区域的灰质体积、灰质/白质表面积和层厚度。形态计量学分析表明，性别和偏侧性可能对 BPD（n=36）和 SCZ（n=31）中 PT 的大小和形状有影响，SCZ 患者的 PT 偏侧性降低，但 BPD 患者没有。此外，PT 表面积在男性中更大，而 BPD 中 PT 表面积的不对称性更大。SCZ 患者的 PT 体积变薄，不对称性更小。因此，与 STG 相比，PT 可能在 SCZ 中观察到的结构异常中发挥更敏感的作用。
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