精神分裂症听觉幻觉的结构相关性：一项荟萃分析。
Structural correlates of auditory hallucinations in schizophrenia: a meta-analysis.
机构信息
Division of Psychiatry, University of Nottingham, A Floor, South Block, Queen's Medical Centre, Nottingham, NG7 2UH, UK.
出版信息
Schizophr Res. 2012 May;137(1-3):169-73. doi: 10.1016/j.schres.2012.01.038. Epub 2012 Feb 16.
BACKGROUND
Despite being one of the most common symptoms of schizophrenia, determining the neural correlates of auditory hallucinations still remains elusive with various studies providing inconsistent results.
METHODS
We conducted a voxel-based meta-analysis of studies investigating the structural correlates of auditory hallucinations in schizophrenia.
RESULTS
7 datasets including 350 patients were identified. There was a significant negative correlation between the severity of hallucinations and gray matter volume in the left insula and right superior temporal gyrus.
CONCLUSION
With its key role in stimulus evaluation and optimizing prediction (proximal salience), the insula is likely to be a cardinal region along with superior temporal gyrus in the mechanism of auditory hallucinations in schizophrenia.
背景
尽管听觉幻觉是精神分裂症最常见的症状之一，但确定其神经相关性仍然难以捉摸，因为各种研究的结果并不一致。
方法
我们对研究精神分裂症听觉幻觉结构相关性的研究进行了基于体素的荟萃分析。
结果
确定了 7 个数据集，其中包括 350 名患者。幻觉的严重程度与左侧脑岛和右侧颞上回的灰质体积呈显著负相关。
结论
脑岛在刺激评估和优化预测（近端显着性）中起着关键作用，因此它很可能是精神分裂症听觉幻觉机制中与颞上回一样重要的区域。
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