四链体在高级 DNA 结构中的解链。
G-quadruplex unfolding in higher-order DNA structures.
机构信息
Dipartimento di Scienze Farmaceutiche, Università di Salerno, Via Ponte Don Melillo, 84084, Fisciano (SA), Italy.
出版信息
Chem Commun (Camb). 2013 Oct 21;49(82):9488-90. doi: 10.1039/c3cc44560g.
PMID:24013385
Abstract
G-quadruplex unfolding within a sequence of two quadruplex units was characterized by gel electrophoresis, calorimetry and spectroscopy. The obtained results suggest that the kinetics and thermodynamics of the individual quadruplex unfolding are affected by its interaction with other DNA secondary structural elements.
摘要
通过凝胶电泳、量热法和光谱法研究了两个四联体单元序列内的 G-四链体展开情况。研究结果表明，单个四链体展开的动力学和热力学受到与其他 DNA 二级结构元件相互作用的影响。
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