神经精神疾病中的异质性与假设检验
Heterogeneity and hypothesis testing in neuropsychiatric illness.
作者信息
Deutsch Curtis K, Ludwig Wesley W, McIlvane William J
机构信息
Eunice Kennedy Shriver Center, University of Massachusetts Medical School.
出版信息
Behav Brain Sci. 2008 Jun;31(3):266-267. doi: 10.1017/S0140525X08004275.
Abstract
The confounding effects of heterogeneity in biological psychiatry and psychiatric genetics have been widely discussed in the literature. We suggest an approach in which heterogeneity may be put to use in hypothesis testing and may find application in evaluation of the Crespi and Badcock (C&B) imprinting hypothesis. Here we consider three potential sources of etiologic subtypes for analysis.
摘要
生物精神病学和精神病遗传学中的异质性所产生的混杂效应在文献中已被广泛讨论。我们提出一种方法，其中异质性可用于假设检验，并可能在评估克雷斯皮和巴德科克（C&B）印记假说中得到应用。在此，我们考虑三种潜在的病因亚型来源以供分析。
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