Schwetz Verena, Lerchbaum Elisabeth, Schweighofer Natascha, Hacker Nicole, Trummer Olivia, Borel Olivier, Pieber Thomas R, Chapurlat Roland, Obermayer-Pietsch Barbara
Division of Endocrinology and Metabolism, Department of Internal Medicine, Medical University of Graz, Graz, Austria.
Hôpital Edouard Herriot, Université de Lyon, INSERM UMR 1033, France.
Endocr Pract. 2014 Jan;20(1):5-14. doi: 10.4158/EP13110.OR.
Osteocalcin (OC) might play a hormone-like role in energy metabolism and the regulatory circuit between the pancreas and osteoblasts. Effects of a 75-g oral glucose tolerance test (OGTT) on total OC, undercarboxylated (ucOC), and carboxylated osteocalcin (cOC) in insulin-resistant (IR) and noninsulin-resistant (nIR) premenopausal women was evaluated, and the relationships of changes in OC, ucOC, and cOC with area under the curve (AUC) insulin and the Matsuda index were examined.
In this cross-sectional study, 105 premenopausal women underwent OGTT; 18 were IR (homeostatic model assessment of insulin resistance [HOMA-IR] > 2.6; (2 with type 2 diabetes, 2 with impaired glucose tolerance), and 87 were nIR (3 with impaired glucose tolerance). Changes in total OC, ucOC, and cOC were evaluated 60 and 120 minutes after glucose loading.
At baseline, IR subjects had significantly lower levels of total OC, cOC, and ucOC. In nIR women, total OC decreased by 19% from 18.0 ng/mL (14.5-24.7) at baseline to 14.6 ng/mL (10.9-17.8) after 120 minutes, ucOC decreased by 22% from 3.2 ng/mL (2.1-4.5) to 2.5 ng/mL (1.7-3.5), and cOC decreased by 26% from 14.9 ng/mL (12.1-20.4) to 11.1 ng/mL (9.0-14.5) (P < .001, respectively). No significant decreases were noted in IR subjects. The declines in OC and cOC predicted AUCinsulin (ΔOC: β = 0.301, P = .001; ΔcOC: β = 0.315, P < .001) and the Matsuda index (ΔOC: β = -0.235, P = .003; ΔcOC: β = -0.245, P = .002).
Glucose intake lowers levels of OC, ucOC, and cOC in nIR women, the extent of which predicts IR and insulin sensitivity in premenopausal women. OC parameters seem suppressed in IR women. There might be a differential osteoblast response to oral glucose in IR and nIR women, with OC reflecting this finding.
骨钙素（OC）可能在能量代谢以及胰腺与成骨细胞之间的调节回路中发挥类似激素的作用。评估了75克口服葡萄糖耐量试验（OGTT）对胰岛素抵抗（IR）和非胰岛素抵抗（nIR）的绝经前女性的总OC、未羧化骨钙素（ucOC）和羧化骨钙素（cOC）的影响，并研究了OC、ucOC和cOC的变化与胰岛素曲线下面积（AUC）和松田指数之间的关系。
在这项横断面研究中，105名绝经前女性接受了OGTT；18名是IR（胰岛素抵抗稳态模型评估[HOMA-IR]＞2.6；2例2型糖尿病，2例糖耐量受损），87名是nIR（3例糖耐量受损）。在葡萄糖负荷后60分钟和120分钟评估总OC、ucOC和cOC的变化。
在基线时，IR受试者的总OC、cOC和ucOC水平显著较低。在nIR女性中，总OC从基线时的18.0 ng/mL（14.5 - 24.7）在120分钟后降至14.6 ng/mL（10.9 - 17.8），下降了19%，ucOC从3.2 ng/mL（2.1 - 4.5）降至2.5 ng/mL（1.7 - 3.5），下降了22%，cOC从14.9 ng/mL（12.1 - 20.4）降至11.1 ng/mL（9.0 - 14.5），下降了26%（P均＜0.001）。IR受试者未观察到显著下降。OC和cOC的下降可预测AUC胰岛素（ΔOC：β = 0.301，P = 0.001；ΔcOC：β = 0.315，P ＜0.001）和松田指数（ΔOC：β = -0.235，P = 0.003；ΔcOC：β = -0.245，P = 0.002）。
摄入葡萄糖会降低nIR女性的OC、ucOC和cOC水平，其降低程度可预测绝经前女性的IR和胰岛素敏感性。IR女性的OC参数似乎受到抑制。IR和nIR女性对口服葡萄糖的成骨细胞反应可能存在差异，OC反映了这一发现。
