Raman N, Sakthivel A, Rajasekaran K
Research Department of Chemistry, VHNSN College, Virudhunagar-626 001, India.
Mycobiology. 2007 Sep;35(3):150-3. doi: 10.4489/MYCO.2007.35.3.150. Epub 2007 Sep 30.
New N2O2 donor type Schiff base has been designed and synthesized by condensing acetoacetanilido-4-aminoantipyrine with 2-aminobenzoic acid in ethanol. Solid metal complexes of the Schiff base with Cu(II), Ni(II), Co(II), Mn(II), Zn(II), VO(IV), Hg(II) and Cd(II) metal ions were synthesized and characterized by elemental analyses, magnetic susceptibility, molar conduction, fast atom bombardment (FAB) mass, IR, UV-Vis, and (1)H NMR spectral studies. The data show that the complexes have the composition of ML type. The UV-Vis. and magnetic susceptibility data of the complexes suggest a square-planar geometry around the central metal ion except VO(IV) complex which has square-pyramidal geometry. The in vitro antifungal activities of the compounds were tested against fungi such as Aspergillus niger, Aspergillus flavus, Rhizopus stolonifer, Candida albicans, Rhizoctonia bataicola and Trichoderma harizanum. All the metal complexes showed stronger antifungal activities than the free ligand. The minimum inhibitory concentrations (MIC) of the metal complexes were found in the range of 10~31 µg/ml.
通过乙酰乙酰苯胺基 - 4 - 氨基安替比林与2 - 氨基苯甲酸在乙醇中缩合，设计并合成了新型N2O2供体型席夫碱。合成了席夫碱与Cu(II)、Ni(II)、Co(II)、Mn(II)、Zn(II)、VO(IV)、Hg(II)和Cd(II)金属离子的固体金属配合物，并通过元素分析、磁化率、摩尔电导率、快原子轰击（FAB）质谱、红外光谱、紫外可见光谱和(1)H核磁共振光谱研究对其进行了表征。数据表明这些配合物具有ML型组成。配合物的紫外可见光谱和磁化率数据表明，除具有四方锥几何构型的VO(IV)配合物外，中心金属离子周围具有平面正方形几何构型。测试了这些化合物对黑曲霉、黄曲霉、匍枝根霉、白色念珠菌、烟草立枯丝核菌和哈茨木霉等真菌的体外抗真菌活性。所有金属配合物均表现出比游离配体更强的抗真菌活性。发现金属配合物的最低抑菌浓度（MIC）在10~31 µg/ml范围内。
