Maitra Souvik, Baidya Dalim Kumar, Khanna Puneet
Department of Anesthesiology and Intensive Care, All India Institute of Medical Sciences, New Delhi, India.
Saudi J Anaesth. 2013 Jul;7(3):315-21. doi: 10.4103/1658-354X.115316.
Melatonin, a new addition to the armamentarium of anesthesiologist, has some unique properties that are highly desirable in routine peri-operative care. Available clinical data show that preoperative melatonin is as effective as benzodiazepines in reducing preoperative anxiety with minimal action on psychomotor performance and sleep wake cycle. It may be considered as a safe and effective alternative of benzodiazepines as preoperative anxiolytic. It may have opioid sparing effect, may reduce intraocular pressure, and have role in prevention of postoperative delirium. The short-term administration of melatonin is free from significant adverse effects also.
褪黑素是麻醉医生可用药物中的新成员，具有一些独特特性，这些特性在常规围手术期护理中非常理想。现有临床数据表明，术前使用褪黑素在减轻术前焦虑方面与苯二氮䓬类药物同样有效，对精神运动表现和睡眠-觉醒周期的影响最小。它可被视为苯二氮䓬类药物作为术前抗焦虑药的安全有效替代品。它可能具有节省阿片类药物的作用，可能降低眼压，并在预防术后谵妄中发挥作用。短期使用褪黑素也没有明显的不良反应。
