Sudhakar C, Pande G
Centre for Cellular and Molecular Biology, Hyderabad, India.
Indian J Exp Biol. 1990 May;28(5):401-4.
Organisation and expression of c-myb protooncogene have been studied in a heterogeneous tumour the Zajdela ascitic hepatoma (ZAH). The myb gene is selectively amplified in the more tumorigenic subpopulation of the tumour while the non-lethal subpopulation does not show any change. Analysis of transcripts of the myb gene in tumorigenic versus nontumorigenic cells shows that the level of amplification of the gene does not correspond to the level of its transcription. Results have been discussed in the light of existing evidence regarding the role of c-myb gene expression during cell cycle.
在一种异质性肿瘤——扎伊德拉萨腹水肝癌（ZAH）中，对c-myb原癌基因的组织和表达进行了研究。myb基因在肿瘤中更具致瘤性的亚群中选择性扩增，而非致死性亚群则未显示任何变化。对致瘤细胞与非致瘤细胞中myb基因转录本的分析表明，该基因的扩增水平与其转录水平并不对应。根据关于c-myb基因表达在细胞周期中的作用的现有证据，对结果进行了讨论。
