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[同种异体骨髓移植治疗肝炎后再生障碍。缓解超过2年。完全造血嵌合体持续存在。移植物抗宿主反应]

[Post-hepatitic aplasia treated by grafts of allogenic bone marrow. Remission for more than 2 years. Persistance of a total hematopoietic chimera. Graft versus host reaction].

作者信息

Rochant H, Mannoni P, Brun B, Beaujean F, Kritvitzki A, Duval J, Dreyfus B

出版信息

Nouv Presse Med. 1975 Apr 19;4(16):1183-8.

PMID:240153
Abstract

A successfull bone marrow transplant was achieved in a case of post hepatitic aplastic anemia after cyclophosphamide immunosuppression. Caryotype analysis, erythrocytic phenotype and IgG Gm allotype demonstrated evidence of complete chimerism. Anti-thymocyte serum undoubtly was able to suppress a life threatening episode of graft versus host reaction. Severe long lasting skin lesions are now persisting 2 years after the graft.

摘要

1例肝炎后再生障碍性贫血患者在环磷酰胺免疫抑制后成功进行了骨髓移植。染色体组型分析、红细胞表型和IgG Gm同种异型均显示完全嵌合的证据。抗胸腺细胞血清无疑能够抑制危及生命的移植物抗宿主反应发作。移植后2年,严重且持久的皮肤病变仍然存在。

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