Ren Xiaomin, Liu Ping
School of Biomedical Engineering, Shanghai Jiao Tong University, Shanghai 200240.
Zhongguo Yi Liao Qi Xie Za Zhi. 2013 May;37(3):157-62.
To develop a novel thermal treatment modality against metastatic tumor, and to verify the hypothesis that the extent of tumor angiogenesis damage and tumor cell necrosis, accompanied with immune suppression cells relief is deterministic to enhance therapeutic effect in the thermal treatment.
The thermal treatment system was developed in our laboratory. The treatment including hyperthermia and alternate treatment, were locally applied to 4T1 murine mammary carcinoma. The extent of tumor necrosis was examined. Further investigations were performed to study the changes of MDSCs in peripheral blood and spleen.
The alternate treatment caused more damage to tumor microvasculature and tumor cell necrosis. Immunosuppression cells significantly reduced in peripheral blood and spleen. Moreover, it highly increased the survival rate of tumor-bearing mice.
The greatest destruction of primary tumor induced by the alternate treatment led to a relief of immune suppression in tumor bearing mice, and significantly increased therapeutic effect, especially for metastatic tumor.
开发一种针对转移性肿瘤的新型热处理方式，并验证以下假设：肿瘤血管生成损伤程度、肿瘤细胞坏死以及免疫抑制细胞的缓解对增强热处理的治疗效果具有决定性作用。
在我们实验室开发了热处理系统。将包括热疗和交替治疗在内的治疗方法局部应用于4T1小鼠乳腺癌。检查肿瘤坏死程度。进一步进行研究以探讨外周血和脾脏中髓源性抑制细胞（MDSCs）的变化。
交替治疗对肿瘤微血管和肿瘤细胞坏死造成了更大的损伤。外周血和脾脏中的免疫抑制细胞显著减少。此外，它显著提高了荷瘤小鼠的存活率。
交替治疗对原发性肿瘤造成的最大破坏导致荷瘤小鼠免疫抑制的缓解，并显著提高了治疗效果，尤其是对转移性肿瘤。
