用于细胞成像的铜（Ⅱ）响应双模（光学/MRI）对比剂。
Cu(2+)-responsive bimodal (optical/MRI) contrast agent for cellular imaging.
机构信息
Department of Chemistry, Korea University , Seoul, 136-704, South Korea, Division of MR Research, Korea Basic Science Institute , Cheongwon 363-883, South Korea, and Graduate School of Analytical Science and Technology, Chungnam National University , Daejeon 305-764, South Korea.
出版信息
Org Lett. 2013 Sep 20;15(18):4702-5. doi: 10.1021/ol4025293. Epub 2013 Sep 9.
A water-soluble T1 magnetic resonance imaging contrast agent (1) has been synthesized. The bimodal contrast agent 1 responds to the Cu(2+) ion in living cells by enhancing the MRI modality signal whereas the optical signal gradually drops. This dual modality probe response depends on the cellular free copper ions in RAW 264.7 cells even at the micromolar level.
一种水溶性 T1 磁共振成像造影剂（1）已被合成。双模态造影剂 1 通过增强 MRI 模式信号来响应活细胞中的 Cu(2+)离子，而光学信号逐渐下降。这种双模式探针响应取决于 RAW 264.7 细胞中的游离铜离子，即使在微摩尔水平也是如此。
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