Hsiao Ya-Shan, Narhe Bharat D, Chang Ying-Sheng, Sun Chung-Ming
Department of Applied Chemistry, National Chiao-Tung University , Hsinchu 300-10, Taiwan.
ACS Comb Sci. 2013 Oct 14;15(10):551-5. doi: 10.1021/co400075z. Epub 2013 Sep 9.
A one-pot, two-step synthesis of imidazo[1,2-a]benzimidazoles has been achieved by a three-component reaction of 2-aminobenzimidazoles with an aromatic aldehyde and an isocyanide. The reaction involving condensation of 2-aminobenzimidazole with an aldehyde is run under microwave activation to generate an imine intermediate under basic conditions which then undergoes [4 + 1] cycloaddition with an isocyanide.
通过2-氨基苯并咪唑与芳香醛和异腈的三组分反应，实现了一锅两步合成咪唑并[1,2-a]苯并咪唑。涉及2-氨基苯并咪唑与醛缩合的反应在微波活化下进行，在碱性条件下生成亚胺中间体，然后该中间体与异腈发生[4 + 1]环加成反应。
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