Eye Department, St. Francis Hospital, Muenster, Germany.
J Refract Surg. 2013 Sep;29(9):612-6. doi: 10.3928/1081597X-20130819-02.
To evaluate the potential influence of corneal cross-linking (CXL) with ultraviolet-A light and riboflavin in keratoconic eyes on several objective parameters of dry eye syndrome.
This prospective single center study included 30 consecutive eyes of 16 patients that underwent CXL with riboflavin and ultraviolet-A treatment (epithelial removal, 30 minutes soaking with riboflavin, 30 minutes of illumination with 365 nm, 3 mW/cm(2), 5 cm distance). Several dry eye syndrome parameters were evaluated preoperatively and 3 and 6 months after the procedure: intra-individual comparison of fluorescein and Rose bengal staining, height of tear film meniscus, and tear film break-up time.
Pathologic staining (more than 10 point-shaped areas or diffuse staining) with fluorescein was evident before CXL in 1 eye, 3 months after CXL in 1 eye, and 6 months after CXL in 1 eye. Rose bengal staining 3 and 6 months postoperatively was comparable to preoperative staining. Tear film height was reduced in 2 eyes before CXL and in 4 eyes 3 months postoperatively, and was normal in all eyes after 6 months. The number of eyes with reduced tear film break-up time was not significantly changed.
CXL had no significant impact on several parameters of dry eye syndrome 3 and 6 months postoperatively.
评估紫外线 A 光和核黄素角膜交联术（CXL）对圆锥角膜眼几种干眼综合征客观参数的潜在影响。
本前瞻性单中心研究纳入了 16 例患者的 30 只连续眼，这些患者接受了核黄素和紫外线 A 治疗的 CXL（上皮去除，用核黄素浸泡 30 分钟，用 365nm、3mW/cm²、5cm 距离的光照射 30 分钟）。在术前和术后 3 个月和 6 个月评估了几种干眼综合征参数：个体内比较荧光素和孟加拉玫瑰红染色、泪膜新月形高度和泪膜破裂时间。
在 CXL 前 1 只眼、CXL 后 3 个月 1 只眼和 CXL 后 6 个月 1 只眼存在病理性荧光素染色（超过 10 个点状区域或弥漫性染色）。术后 3 个月和 6 个月的 Rose Bengal 染色与术前染色相当。在 CXL 前 2 只眼和 CXL 后 3 个月 4 只眼的泪膜高度降低，而在术后 6 个月所有眼的泪膜高度均正常。泪膜破裂时间减少的眼数无明显变化。
CXL 在术后 3 个月和 6 个月对干眼综合征的几个参数没有显著影响。
