Wang Jing, Sun Wei-jie, Yang Hui-xia
Department of Obstetrics and Gynecology, Peking University First Hospital, Beijing, China.
Zhonghua Fu Chan Ke Za Zhi. 2013 May;48(5):330-3.
To explore the normal range of serum glycated albumin (GA) during the second trimester in non-gestational diabetes mellitus (GDM) population and the value of serum GA in the blood glucose monitoring during pregnancy.
The GA was measured in 101 healthy gravida during the second trimester and 80 gravida with GDM and diabetes mellitus who were in treatment at Peking University First Hospital between August 2011 and December 2011, in order to analyze the normal range of GA and the relationship between GA and the level of blood glucose.
(1) The normal range of GA during the second trimester was 10.9%-15.3%, which was negatively correlated with body mass index (P < 0.01). (2) Significant correlations were observed between GA and the level of hemoglobin A1c (HbA1c), preprandial, postprandial and mean plasma glucose in gravida with GDM and diabetes mellitus (r:0.361, 0.252, 0.338, 0.310;all P < 0.05). (3) When the level of GA was 13.97%, the sensitivity and specificity index for glucose control were 78.0% and 74.4%.
GA could evaluate the severity of disease in gravida with GDM and diabetes mellitus. 10.9%-15.3% could be suggested as normal range of GA for the gravida at the second trimester.
探讨非妊娠期糖尿病（GDM）人群孕中期血清糖化白蛋白（GA）的正常范围以及血清GA在孕期血糖监测中的价值。
对2011年8月至2011年12月期间在北京大学第一医院就诊的101例健康孕妇及80例GDM和糖尿病孕妇进行GA检测，以分析GA的正常范围以及GA与血糖水平的关系。
（1）孕中期GA的正常范围为10.9% - 15.3%，与体重指数呈负相关（P < 0.01）。（2）在GDM和糖尿病孕妇中，GA与糖化血红蛋白（HbA1c）、餐前、餐后及平均血糖水平之间存在显著相关性（r分别为0.361、0.252、0.338、0.310；均P < 0.05）。（3）当GA水平为13.97%时，血糖控制的敏感性和特异性指标分别为78.0%和74.4%。
GA可评估GDM和糖尿病孕妇的疾病严重程度。建议将10.9% - 15.3%作为孕中期孕妇GA的正常范围。
