Liu Bo, Feng Wen-jing, Peng Xiao-xia, Yang Jian
Department of Otorhinolaryngology Head and Neck Surgery, Capital Medical University, Beijing, China.
Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2013 May;48(5):417-21.
To investigate the correlation between prothrombin G20210A polymorphism and the risk for idiopathic sudden sensorineural hearing loss (ISSNHL) using Meta-analysis methodology.
Databases, including PUBMED, EMBASE, Cochrane Library and CBM, were searched to collect the case control studies on the correlation between prothrombin G20210A polymorphism and idiopathic sudden sensorineural hearing loss. Only high quality studies were included. All analysis were conducted with Review Manager Version 4.2 software.
A total of 9 studies were included, involving 735 cases and 1230 controls. The quality assessment involved 3 parts, 8 scores (totally 8 stars). The results showed the included studies were high-quality. Two studies were 8 stars of quality, three studies were 7 stars, one study was 6 stars, one study was 5 stars, and two studies were 4 stars. Meta-analysis showed that the prothrombin G20210A mutation frequencies of the genotypes and alleles showed significant statistically difference between cases and controls [P = 0.03, OR = 1.79, 95% CI = (1.06, 3.01); P = 0.03, OR = 1.77, 95% CI = (1.06, 2.97), respectively].
The prothrombin G20210A polymorphism might be a genetic risk factor for sudden hearing loss. However, this conclusion remains to be confirmed by high-quality, large-scale studies.
采用Meta分析方法探讨凝血酶原G20210A基因多态性与特发性突发性感音神经性听力损失（ISSNHL）风险之间的相关性。
检索包括PUBMED、EMBASE、Cochrane图书馆和中国生物医学文献数据库（CBM）在内的数据库，收集关于凝血酶原G20210A基因多态性与特发性突发性感音神经性听力损失相关性的病例对照研究。仅纳入高质量研究。所有分析均使用Review Manager 4.2版软件进行。
共纳入9项研究，涉及735例病例和1230例对照。质量评估包括3部分，共8分（满分8星）。结果显示纳入的研究质量较高。两项研究为8星质量，三项研究为7星，一项研究为6星，一项研究为5星，两项研究为4星。Meta分析显示，病例组和对照组之间基因型和等位基因的凝血酶原G20210A突变频率在统计学上有显著差异[P = 0.03，OR = 1.79，95%CI =（1.06，3.01）；P = 0.03，OR = 1.77，95%CI =（1.06，2.97）]。
凝血酶原G20210A基因多态性可能是突发性听力损失的一个遗传风险因素。然而，这一结论仍有待高质量、大规模研究证实。
