Laboratório de Antibióticos, MIP, Universidade Federal de Santa Catarina (UFSC), Campus Trindade, CEP: 88040-900 Florianópolis, SC, Brazil; Departamento de Odontologia, CEPID, CCS, Universidade Federal de Santa Catarina (UFSC), Campus Trindade, CEP: 88040-900 Florianópolis, SC, Brazil.
Int J Antimicrob Agents. 2013 Dec;42(6):519-23. doi: 10.1016/j.ijantimicag.2013.07.006. Epub 2013 Aug 12.
New unconventional approaches to the development of antimicrobial drugs must target inhibition of infection stages leading to host colonisation or virulence itself, rather than bacterial viability. Amongst the most promising unconventional targets for the development of new antimicrobial drugs is bacterial adherence and biofilm formation as well as their control system, the quorum-sensing (QS) system, a mechanism of communication used to co-ordinate bacterial activities. Here we describe the evaluation of synthetic organic compounds as bacterial biofilm inhibitors against a panel of clinically relevant Gram-positive and Gram-negative bacterial strains. This approach has successfully allowed the identification of five compounds (GEt, GHex, GOctad, G19 and C33) active not only against bacterial biofilms but also displaying potential to be used as antagonists and/or inhibitors of bacterial QS.
新的非传统方法开发抗菌药物必须针对抑制导致宿主定植或毒力本身的感染阶段，而不是细菌的存活能力。在开发新抗菌药物最有前途的非传统靶点中，细菌黏附和生物膜形成及其控制系统——群体感应 (QS) 系统是一种用于协调细菌活动的通讯机制。在这里，我们描述了合成有机化合物作为抗临床相关革兰氏阳性和革兰氏阴性细菌菌株的生物膜抑制剂的评估。这种方法成功地鉴定了五种化合物（GEt、GHex、GOctad、G19 和 C33），它们不仅对细菌生物膜具有活性，而且具有作为细菌 QS 的拮抗剂和/或抑制剂的潜力。
