纳洛酮可抑制男性性高潮时的催产素释放。
Naloxone inhibits oxytocin release at orgasm in man.
作者信息
Murphy M R, Checkley S A, Seckl J R, Lightman S L
机构信息
Institute of Psychiatry, De Crespigny Park, Denmark Hill, London, England.
出版信息
J Clin Endocrinol Metab. 1990 Oct;71(4):1056-8. doi: 10.1210/jcem-71-4-1056.
We examined the effect of naloxone on plasma oxytocin levels during sexual activity in men. Eight normal men took part in a double-blind, two-period, cross-over design. Mean plasma oxytocin rose to 362% of baseline values at orgasm with placebo (saline) but showed no increase with naloxone (P less than 0.01). While naloxone had no effect on heart rate or blood pressure at orgasm, a decrease in the level of subjective arousal and pleasure at orgasm was noted. We conclude that opioid receptor blockade with naloxone has an inhibitory effect on the neural pathways mediating the oxytocin response at orgasm.
我们研究了纳洛酮对男性性活动期间血浆催产素水平的影响。八名正常男性参与了一项双盲、两阶段、交叉设计的研究。使用安慰剂（生理盐水）时，平均血浆催产素在性高潮时升至基线值的362%，但使用纳洛酮时未出现升高（P<0.01）。虽然纳洛酮对性高潮时的心率或血压没有影响，但观察到性高潮时主观唤起和愉悦程度有所下降。我们得出结论，纳洛酮阻断阿片受体对介导性高潮时催产素反应的神经通路具有抑制作用。
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