Kazer R R, Unterman T G, Glick R P
Department of Obstetrics and Gynecology, Northwestern University Medical School, Chicago, Illinois.
J Clin Endocrinol Metab. 1990 Oct;71(4):958-62. doi: 10.1210/jcem-71-4-958.
To investigate the GH/insulin-like growth factor-I (IGF-I) axis in women with polycystic ovary syndrome (PCO), we measured serum concentrations of GH over a 14-h period (0900-2300 h) in 10 women with this disorder using an ambulatory exfusion pump. The same study was carried out in 9 age- and weight-matched normal cycling women who served as controls. Mean (+/- SE) serum GH concentrations over the 14-h period were markedly lower in the subjects with PCO (0.6 +/- 0.2 vs. 1.8 +/- 0.3 micrograms/L; P less than 0.005). Eight of 10 subjects with PCO had mean serum GH concentrations below 1.2 micrograms/L, while only 1 of 9 control subjects had corresponding values below this concentration. In contrast, mean circulating serum concentrations of IGF-I were indistinguishable in the 2 groups. We conclude from these data that PCO is characterized by decreased serum GH concentrations in the face of normal serum IGF-I concentrations. The mechanisms underlying this alteration in the GH/IGF-I axis and its role in the pathogenesis of PCO remain to be clarified.
为研究多囊卵巢综合征（PCO）女性的生长激素（GH）/胰岛素样生长因子-I（IGF-I）轴，我们使用便携式输液泵在10名患有该疾病的女性中，于14小时内（09:00 - 23:00）测量血清GH浓度。在9名年龄和体重匹配的正常月经周期女性作为对照进行了同样的研究。PCO患者在14小时内的平均（±标准误）血清GH浓度显著低于对照组（0.6±0.2对1.8±0.3微克/升；P<0.005）。10名PCO患者中有8名的平均血清GH浓度低于1.2微克/升，而9名对照受试者中只有1名的相应值低于此浓度。相比之下，两组中IGF-I的平均循环血清浓度无明显差异。从这些数据我们得出结论，PCO的特征是在血清IGF-I浓度正常的情况下血清GH浓度降低。GH/IGF-I轴这种改变的潜在机制及其在PCO发病机制中的作用仍有待阐明。
