低水平的高密度脂蛋白胆固醇可预测主动脉瘤患者是否存在冠状动脉疾病。

Low levels of high-density lipoprotein cholesterol predict the presence of coronary artery disease in patients with aortic aneurysms.

机构信息

Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan.

Department of Cardiovascular Medicine, Shinshu University School of Medicine, Matsumoto, Japan

出版信息

Angiology. 2014 Sep;65(8):710-5. doi: 10.1177/0003319713502391. Epub 2013 Sep 9.

DOI:10.1177/0003319713502391

PMID:24019083

Abstract

To identify predictors of the presence of coronary artery disease (CAD) in patients with planned surgery for aortic aneurysms, we reviewed clinical profiles and angiography records of 191 patients with aortic aneurysms (34 thoracic, 137 abdominal, and 20 thoracoabdominal; 162 men; mean age, 75.2 ± 7.7 years). The incidence of CAD was 38.7% among all the patients. Patients with CAD had significantly low levels of high-density lipoprotein cholesterol (HDL-C) as compared with patients without CAD (45 ± 9 vs 51 ± 13 mg/dL; P = .009). Multivariate analysis showed that only low HDL-C levels were associated with the presence of CAD (adjusted odds ratio, 0.946; 95% confidence interval, 0.911-0.983; P = .004). The optimal cutoff level of HDL-C to predict CAD was 47.50 mg/dL. The CAD is common in patients with aortic aneurysms, and low levels of HDL-C are independently associated with the presence of CAD.

摘要

为了确定计划接受主动脉瘤手术的患者中存在冠状动脉疾病 (CAD) 的预测因素，我们回顾了 191 例主动脉瘤患者（34 例胸主动脉瘤，137 例腹主动脉瘤和 20 例胸腹主动脉瘤；162 例男性；平均年龄 75.2 ± 7.7 岁）的临床资料和血管造影记录。所有患者的 CAD 发生率为 38.7%。与无 CAD 的患者相比，CAD 患者的高密度脂蛋白胆固醇 (HDL-C) 水平明显较低（45 ± 9 与 51 ± 13 mg/dL；P =.009）。多变量分析显示，只有低 HDL-C 水平与 CAD 的存在相关（校正优势比，0.946；95%置信区间，0.911-0.983；P =.004）。预测 CAD 的 HDL-C 最佳截断值为 47.50 mg/dL。CAD 在主动脉瘤患者中很常见，而低水平的 HDL-C 与 CAD 的存在独立相关。