尼日利亚卡拉巴尔和乌约市血管紧张素II 1型受体A1166C基因多态性与原发性高血压
Angiotensin II type 1 receptor A1166C gene polymorphism and essential hypertension in Calabar and Uyo cities, Nigeria.
作者信息
Kooffreh Mary Esien, Anumudu Chiaka Ijeoma, Duke Roseline, Okpako Elza Cletus, Kumar P Lava
机构信息
Department of Genetics and Biotechnology, University of Calabar, Nigeria.
出版信息
Indian J Hum Genet. 2013 Apr;19(2):213-8. doi: 10.4103/0971-6866.116120.
OBJECTIVES
The angiotensin II protein is a vasoconstrictor that exerts most of its influence through the angiotensin II type 1 receptor (AT1R). Inconsistent association between the A1166C polymorphism of the AT1R gene and hypertension has been reported among various populations but not among the peoples of Calabar and Uyo. This study was designed to determine the frequency of the A1166C polymorphism of the AT1R gene and its association with hypertension in a sample population of Calabar and Uyo.
MATERIALS AND METHODS
A population-based case control design consisting of total of 1224 participants, 612 each of patients and controls were randomly recruited from hypertension clinics and the general population. Genotyping of the A1166C allele of the AT1R gene to identify variants was performed using polymerase chain reaction and restriction enzyme digestion. Multiple regressions were applied to test whether the A1166 genotypes were predictors of hypertension.
RESULTS
99% of the study population had the wild type AA genotype, and 1% was AC heterozygous carriers of the A1166C polymorphism.
CONCLUSION
The A1166C polymorphism was not a predictor of hypertension in the sample population of Calabar and Uyo.
目的
血管紧张素II蛋白是一种血管收缩剂，其大部分作用是通过血管紧张素II 1型受体（AT1R）发挥的。在不同人群中，AT1R基因A1166C多态性与高血压之间的关联并不一致，在卡拉巴尔和乌约人群中尚未见报道。本研究旨在确定卡拉巴尔和乌约样本人群中AT1R基因A1166C多态性的频率及其与高血压的关联。
材料与方法
采用基于人群的病例对照设计，共纳入1224名参与者，其中612名患者和612名对照分别从高血压诊所和普通人群中随机招募。使用聚合酶链反应和限制性酶切对AT1R基因的A1166C等位基因进行基因分型以鉴定变异。应用多元回归分析来检验A1166基因型是否为高血压的预测指标。
结果
99%的研究人群具有野生型AA基因型，1%为A1166C多态性的AC杂合携带者。
结论
在卡拉巴尔和乌约的样本人群中，A1166C多态性不是高血压的预测指标。
Zotero 插件