Department of Human Biology, Faculty of Health Sciences, Walter Sisulu University, Mthatha, South Africa.
Diabetes Research Center and Diabetes Clinic, Department of Internal Medicine, Free University of Brussels, Brussels, Belgium.
J Clin Hypertens (Greenwich). 2018 Mar;20(3):485-495. doi: 10.1111/jch.13225. Epub 2018 Mar 9.
In a systematic review, the authors explored genetic association studies of essential hypertension in African populations. Studies reporting on the association of polymorphism(s) with hypertension in African populations were included. Appropriate studies were pooled using random effects model meta-analysis, under six potential inheritance models. In all, 46 polymorphisms in 33 genes were investigated for their association with hypertension or blood pressure levels. Meta-analysis was possible for three single nucleotide polymorphisms: rs4340, rs699, and rs5186. An association was found between rs5186, rs699, and hypertension under allele contrast and homozygous codominant models (odds ratio, 1.63 [95% confidence interval, 1.04-2.54] and 4.01 [95% confidence interval, 1.17-13.80] for rs5186, respectively; and 1.80 [95% confidence interval, 1.13-2.87] for rs699). Findings were mostly robust in sensitivity analyses. According to the systematic review, there is currently insufficient evidence on the specific polymorphisms that pose the risk of hypertension in African populations. Large-scale genetic studies are warranted to better understand susceptibility polymorphisms that may be specific to African populations.
在一项系统评价中，作者探讨了非洲人群原发性高血压的遗传关联研究。纳入了报告非洲人群中多态性与高血压关联的研究。使用随机效应模型荟萃分析，在六种潜在遗传模式下，对适当的研究进行了汇总。总共研究了 33 个基因中的 46 个多态性与高血压或血压水平的关联。对于三个单核苷酸多态性（rs4340、rs699 和 rs5186）进行了荟萃分析。rs5186、rs699 与高血压在等位基因对比和纯合子显性模型下存在关联（比值比分别为 1.63[95%置信区间为 1.04-2.54]和 4.01[95%置信区间为 1.17-13.80]）；rs699 的比值比为 1.80[95%置信区间为 1.13-2.87]）。敏感性分析结果基本稳健。根据系统评价，目前尚无关于非洲人群中导致高血压的特定多态性的充分证据。需要进行大规模的遗传研究，以更好地了解可能特定于非洲人群的易感性多态性。
