Rafay A M
Department of Microbiology, College of Medicine, Sultan Qaboos University, P.O.Box: 35, Postal Code: 123, Muscat, Sultanate of Oman.
J Sci Res Med Sci. 2000 Jan;2(1):25-31.
The increase in resistance to gram positive organisms and seriousness of infective endocarditis, makes it necessary to look for an alternate treatment.
In-vitro activity of synercid was compared with penicillin, amoxycillin, teicoplanin, vancomycin, clindamycin and erythromycin.
Synercid showed minimum inhibitory concentrations (MIC) within the narrow range of 0.06 - 0.5 mg/l. MIC50 and mode values were both 0.25 mg/l. There was just two-fold difference between the MIC50 (0.25 mg/l) and the MIC90, (0.5 mg/l). Although the MICs of synercid for S. oralis were relatively high compared to penicillin, clindamycin, erythromycin and teicoplanin, the in-vitro bactericidal activity of synercid was much greater. Synercid MBC values were < 4 mg/l for most of the isolates, except for one of 16 mg/l and the other >64 mg/l. Killing curve was performed on six isolates of S. oralis from infective endocarditis, two from septicaemia patients and two from the oral flora of normal individuals.
Synercid showed superior bactericidal activity when compared to penicillin and vancomycin against all ten isolates of S. oralis tested. Synercid was bactericidal (99.9% kill) against all ten isolates of S. oralis within six hours of contact.
革兰氏阳性菌耐药性的增加以及感染性心内膜炎的严重性，使得有必要寻找替代治疗方法。
将速溶链霉素的体外活性与青霉素、阿莫西林、替考拉宁、万古霉素、克林霉素和红霉素进行比较。
速溶链霉素的最低抑菌浓度（MIC）在0.06 - 0.5毫克/升的窄范围内。MIC50和众数均为0.25毫克/升。MIC50（0.25毫克/升）和MIC90（0.5毫克/升）之间只有两倍的差异。尽管与青霉素、克林霉素、红霉素和替考拉宁相比，速溶链霉素对口腔链球菌的MIC相对较高，但其体外杀菌活性要大得多。除了一株为16毫克/升和另一株>64毫克/升外，大多数分离株的速溶链霉素MBC值<4毫克/升。对来自感染性心内膜炎的6株口腔链球菌、2株败血症患者和2株正常个体口腔菌群的分离株进行了杀菌曲线测定。
与青霉素和万古霉素相比，速溶链霉素对所有10株测试的口腔链球菌均显示出优异的杀菌活性。速溶链霉素在接触6小时内对所有10株口腔链球菌均具有杀菌作用（杀灭率99.9%）。
