Matsuzaki Hiroshi, Koga Yuhki, Suminoe Aiko, Oba Utako, Takimoto Tomohito, Hara Toshiro
Department of Pediatrics, Graduate School of Medical Sciences, Kyushu University, Fukuoka, Japan.
Case Rep Oncol. 2013 Jul 31;6(2):397-402. doi: 10.1159/000354271. eCollection 2013.
This is the first paper to report the association of cancer chemotherapy with rhabdomyolysis in children. A previously healthy, 15-year-old Japanese female was diagnosed as having alveolar rhabdomyosarcoma. She received the first cycle of multi-agent chemotherapy without any adverse effects. However, she developed severe acute rhabdomyolysis shortly after the second cycle of multi-agent chemotherapy, which consisted of etoposide, ifosfamide, actinomycin-D and vincristine. Her condition deteriorated rapidly and she was treated with mechanical ventilation and fluid replacement. After further evaluation, anticancer drugs were thought to be responsible for the rhabdomyolysis.
这是首篇报道儿童癌症化疗与横纹肌溶解症之间关联的论文。一名此前健康的15岁日本女性被诊断患有肺泡横纹肌肉瘤。她接受了首个周期的多药联合化疗，未出现任何不良反应。然而，在第二个周期的多药联合化疗（包括依托泊苷、异环磷酰胺、放线菌素-D和长春新碱）后不久，她出现了严重的急性横纹肌溶解症。她的病情迅速恶化，接受了机械通气和液体补充治疗。经过进一步评估，抗癌药物被认为是导致横纹肌溶解症的原因。
