左旋多巴反应性良性震颤型帕金森综合征

Levodopa-responsive benign tremulous parkinsonism.

作者信息

Kano Osamu, Okonogi Shinichi, Hanashiro Sayori, Miura Ken, Ikeda Ken, Iwasaki Yasuo

机构信息

Department of Neurology, Toho University Omori Medical Center, Tokyo, Japan.

出版信息

Case Rep Neurol. 2013 Aug 28;5(2):139-42. doi: 10.1159/000354980. eCollection 2013.

DOI:10.1159/000354980

PMID:24019787

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3764968/

Abstract

BACKGROUND

Benign tremulous parkinsonism (BTP) is a tremor dominant syndrome characterized by mild, levodopa-resistant parkinsonism with limited disability or progression.

CASE PRESENTATION

A 56-year-old woman presented with a 2-year history of tremor. Neurological examination revealed right-hand rest tremor and slow finger tapping with decreased amplitude; however, we did not observe posture tremor, rigidity, bradykinesia, or posture disability. She was diagnosed with Parkinson's disease (PD) and received levodopa/carbidopa, effectively treating her rest tremor. At the age of 61 years, reoccurrence of the rest tremor was successfully treated again with levodopa/carbidopa and selegiline. Approximately 11 years have passed since symptom onset and the patient shows no further disease progression.

CONCLUSION

This case broadens the characterization of BTP to include levodopa-responsive PD.

摘要

背景

良性震颤性帕金森综合征（BTP）是一种以震颤为主的综合征，其特征为轻度、左旋多巴抵抗性帕金森综合征，残疾或病情进展有限。

病例报告

一名56岁女性，有2年震颤病史。神经系统检查发现右手静止性震颤和手指叩击缓慢且幅度减小；然而，我们未观察到姿势性震颤、强直、运动迟缓或姿势性残疾。她被诊断为帕金森病（PD）并接受了左旋多巴/卡比多巴治疗，有效治疗了她的静止性震颤。61岁时，静止性震颤复发，再次使用左旋多巴/卡比多巴和司来吉兰成功治疗。自症状出现以来大约已过去11年，患者未显示出进一步的疾病进展。