Mohrin Mary, Chen Danica
University of California, Berkeley, CA, USA.
Genes Cancer. 2013 Mar;4(3-4):76-81. doi: 10.1177/1947601912474930.
Aging is a degenerative process resulting in compromised tissue maintenance and increased susceptibility to diseases, such as cancer. Recent advancements support the notion that aging is a highly regulated process governed by evolutionarily conserved pathways. In mammals, tissue-specific adult stem cells (ASCs) persist throughout the lifetime to maintain and repair tissues. While reduced ASC self-renewal is thought to contribute to compromised tissue maintenance, increased self-renewal of cancer stem cells (CSCs) may lead to tumorigenesis. It is speculated that genetic regulators of aging, such as sirtuins, are likely to impinge upon the ASC compartments to regulate tissue maintenance and tumorigenesis. In this review, we discuss the emerging evidence linking sirtuins to normal and malignant ASC self-renewal, tissue maintenance, and tumorigenesis.
衰老乃一退行性过程，会导致组织维持功能受损，并增加对诸如癌症等疾病的易感性。近期进展支持这样一种观点，即衰老乃是一个由进化上保守的通路所调控的高度有序的过程。在哺乳动物中，组织特异性成体干细胞（ASC）终生存在以维持和修复组织。虽然ASC自我更新能力的降低被认为会导致组织维持功能受损，但癌症干细胞（CSC）自我更新能力的增强可能会导致肿瘤发生。据推测，衰老的遗传调节因子，如沉默调节蛋白，可能会影响ASC区室以调节组织维持和肿瘤发生。在本综述中，我们讨论了将沉默调节蛋白与正常和恶性ASC自我更新、组织维持及肿瘤发生联系起来的新证据。
