Maiborodin I V, Kuznetsova I V, Beregovoy E A, Shevela A I, Barannik M I, Manayev A A, Maiborodina V I
Center of New Medical Technologies, Institute of Chemical Biology and Fundamental Medicine, RAS, Novosibirsk, Russia
Morfologiia. 2013;143(3):59-65.
Tissue reactions, accompanying the degradation processes of polylactide (PLA) implants after their placement into the subcutaneous tissue, were studied by the methods of light microscopy in 6 month-old Wag rats (n=24) weighing 180-200 g. It was found that PLA implants became encapsulated by connective tissue. If the implant or its fragment had sharp margins that damaged the tissues, a thick capsule was formed with a distinct inflammatory infiltration and the sclerosis of the surrounding tissues. If the implant had no sharp margins, the capsule was thin, and the activity of inflammation was minimal. In all cases, the giant cells of foreign body type were present in the capsule and next to it. Gradually, during 6 months, the activity of inflammatory process subsided. Inflammation sharply increased 12 months after the implantation, when, as a result of effect of enzymes released by phagocytes and deformation by a capsule, PLA implants were either fragmented or is liquified. PLA-based materials are not totally biodegradable, and may persist in the body for a long time.
采用光学显微镜方法，对体重180 - 200克的6月龄Wag大鼠（n = 24）皮下植入聚丙交酯（PLA）植入物后的降解过程伴随的组织反应进行了研究。结果发现，PLA植入物被结缔组织包裹。如果植入物或其碎片边缘锐利并损伤组织，则会形成厚包膜，伴有明显的炎症浸润和周围组织硬化。如果植入物边缘不锐利，则包膜较薄，炎症活动轻微。在所有情况下，包膜及其附近均存在异物型巨细胞。在6个月期间，炎症过程的活动逐渐减弱。植入12个月后，炎症急剧增加，此时由于吞噬细胞释放的酶的作用以及包膜的变形，PLA植入物要么破碎要么液化。基于PLA的材料并非完全可生物降解，可能会在体内长期存留。
