Kageura M, Hara K, Hieda Y, Takamoto M, Morinaga M, Fujiwara Y, Fukuma Y, Kashimura S
Department of Legal Medicine, Fukuoka University School of Medicine.
Nihon Hoigaku Zasshi. 1990 Apr;44(2):126-30.
This paper describes the detection limit for 23 drugs and chemicals in the blood by means of a screening method that uses a gas chromatographic system equipped with a wide-bore capillary column and a nitrogen phosphorus detector. The detection limit by this method was determined as being 1 mm of peak height at the detector's range of 100 and 8 of attenuation. Using this scale, the absolute detection limit was in the range of 1 pg for malathion and sumithion to 1 ng for meprobamate. The detection limit of drugs and chemicals in the blood was 5 ng/ml for sumithion to 8 micrograms/ml for meprobamate. Therefore, this screening method is able to detect the presence of drugs even a therapeutic-level dosages, with the exception of compounds such as haloperidol, which have extremely low therapeutic dosage levels.
本文描述了一种采用配备宽口径毛细管柱和氮磷检测器的气相色谱系统的筛查方法，用于检测血液中23种药物和化学物质的检测限。该方法的检测限在检测器量程为100且衰减为8时，确定为峰高1毫米。按照此标准，马拉硫磷和杀螟松的绝对检测限在1皮克范围内，而眠尔通的绝对检测限在1纳克范围内。血液中药物和化学物质的检测限，杀螟松为5纳克/毫升，眠尔通为8微克/毫升。因此，这种筛查方法能够检测出血液中甚至治疗剂量水平的药物存在，但治疗剂量水平极低的化合物如氟哌啶醇除外。
