Mahiques Santos L, Oliver Martinez V, Alegre de Miquel V
Servicio de Dermatología, Hospital La Plana, Villarreal, Castellón, España.
Servicio de Dermatología, Consorcio Hospital General Universitario de Valencia, Valencia, España.
Actas Dermosifiliogr. 2014 Jan-Feb;105(1):60-8. doi: 10.1016/j.ad.2013.07.003. Epub 2013 Sep 8.
The prognostic value of sentinel lymph node (SLN) biopsy findings and mitotic activity in melanoma has been confirmed in the literature, but the relation between them has not been well established.
The main objective was to describe and analyze the correlation between SLN biopsy results and the mitotic rate in patients treated for melanoma in our hospital.
A total of 139 consecutive patients who underwent SLN biopsy between May 2001 and May 2009 were included. The relation between the mitotic rate and SLN status was analyzed with the χ(2) test and the Fischer exact test.
The correlation between the 2 variables was nonsignificant (P =.071) in the patient series overall, but a significant association was found in the subgroup of patients with tumors of Breslow thickness between 1 and 4mm (P =.034). The likelihood (odds ratio) of SLN positivity with a mitotic rate of less than 1 mitosis/mm2 in this subgroup was 0.838 (95% CI, 0.758-0.926).
Our findings support use of the mitotic rate to predict SLN status in melanoma tumors of intermediate thickness. Our study also shows the need for further investigation of the relation between these 2 variables in thin and thick tumors.
前哨淋巴结（SLN）活检结果及有丝分裂活性在黑色素瘤中的预后价值已在文献中得到证实，但它们之间的关系尚未完全明确。
主要目的是描述和分析我院接受黑色素瘤治疗患者的前哨淋巴结活检结果与有丝分裂率之间的相关性。
纳入2001年5月至2009年5月期间连续接受前哨淋巴结活检的139例患者。采用χ²检验和费舍尔精确检验分析有丝分裂率与前哨淋巴结状态之间的关系。
在整个患者系列中，这两个变量之间的相关性无统计学意义（P = 0.071），但在Breslow厚度为1至4mm的肿瘤患者亚组中发现了显著相关性（P = 0.034）。在该亚组中，有丝分裂率小于1次有丝分裂/平方毫米时前哨淋巴结阳性的可能性（比值比）为0.838（95%可信区间，0.758 - 0.926）。
我们的研究结果支持使用有丝分裂率来预测中等厚度黑色素瘤肿瘤的前哨淋巴结状态。我们的研究还表明，需要进一步研究薄型和厚型肿瘤中这两个变量之间的关系。
