Weiner Kevin S, Golarai Golijeh, Caspers Julian, Chuapoco Miguel R, Mohlberg Hartmut, Zilles Karl, Amunts Katrin, Grill-Spector Kalanit
Department of Psychology, Stanford University, Stanford, CA 94305, USA.
Neuroimage. 2014 Jan 1;84:453-65. doi: 10.1016/j.neuroimage.2013.08.068. Epub 2013 Sep 8.
Human ventral temporal cortex (VTC) plays a pivotal role in high-level vision. An under-studied macroanatomical feature of VTC is the mid-fusiform sulcus (MFS), a shallow longitudinal sulcus separating the lateral and medial fusiform gyrus (FG). Here, we quantified the morphological features of the MFS in 69 subjects (ages 7-40), and investigated its relationship to both cytoarchitectonic and functional divisions of VTC with four main findings. First, despite being a minor sulcus, we found that the MFS is a stable macroanatomical structure present in all 138 hemispheres with morphological characteristics developed by age 7. Second, the MFS is the locus of a lateral-medial cytoarchitectonic transition within the posterior FG serving as the boundary between cytoarchitectonic regions FG1 and FG2. Third, the MFS predicts a lateral-medial functional transition in eccentricity bias representations in children, adolescents, and adults. Fourth, the anterior tip of the MFS predicts the location of a face-selective region, mFus-faces/FFA-2. These findings are the first to illustrate that a macroanatomical landmark identifies both cytoarchitectonic and functional divisions of high-level sensory cortex in humans and have important implications for understanding functional and structural organization in the human brain.
人类腹侧颞叶皮质（VTC）在高级视觉中起关键作用。VTC一个研究较少的大体解剖特征是中梭状沟（MFS），这是一条将外侧和内侧梭状回（FG）分开的浅纵向沟。在这里，我们量化了69名受试者（年龄7至40岁）中MFS的形态特征，并研究了它与VTC细胞结构和功能分区的关系，有四个主要发现。第一，尽管MFS是一条较小的沟，但我们发现它是一个稳定的大体解剖结构，存在于所有138个半球中，其形态特征在7岁时就已发育形成。第二，MFS是后FG内细胞结构从外侧到内侧转变的位点，作为细胞结构区域FG1和FG2之间的边界。第三，MFS预测儿童、青少年和成年人在偏心率偏差表征方面从外侧到内侧的功能转变。第四，MFS的前端预测了一个面部选择性区域mFus-faces/FFA-2的位置。这些发现首次表明，一个大体解剖标志既确定了人类高级感觉皮质的细胞结构分区，也确定了其功能分区，对理解人类大脑的功能和结构组织具有重要意义。
