Seledtsov I A, Solov'ev V V, Merkulova T I
Mol Biol (Mosk). 1990 May-Jun;24(3):716-28.
An analysis of the structure of DNA sites responsible for binding to glucocorticoid-receptor complex (GlRC) was carried out. The use of the frequency matrices and of a variant of the perception method made it possible to establish that in the GlRC binding site on both sides of the known conservative nucleotide sequence (nucleus) there were additional conservative elements which seemed to be able to modulate the efficiency of GlRC binding. A criterion is worked out for detecting the potential GlRC binding sites in given sequences. It is based on the simultaneous use of several perceptron matrices. The efficiency of detection of GlRC binding sites by means of the proposed criterion is by an order higher than that performed according to the GlRC binding site consensus (Beato et al. [2]).
对负责与糖皮质激素受体复合物（GlRC）结合的DNA位点结构进行了分析。通过使用频率矩阵和感知方法的一种变体，得以确定在已知保守核苷酸序列（核心）两侧的GlRC结合位点中存在额外的保守元件，这些元件似乎能够调节GlRC结合的效率。制定了一个用于检测给定序列中潜在GlRC结合位点的标准。它基于同时使用多个感知器矩阵。通过所提出的标准检测GlRC结合位点的效率比根据GlRC结合位点共有序列进行检测的效率高一个数量级（贝托等人[2]）。
