通过注射亲代淋巴细胞改变局部移植物抗宿主反应中的混合反应性

Modification of hybrid responsiveness in the local graft-versus-host reaction by injection of parental lymphocytes.

作者信息

Rose N R

出版信息

Transplantation. 1975 Sep;20(3):248-54. doi: 10.1097/00007890-197509000-00010.

DOI:10.1097/00007890-197509000-00010

Abstract

The local graft-versus-host reaction in F1 hybrid rats, assayed by popliteal lymph node enlargement, is specifically depressed by pretreating the host with parental lymphocytes. The conditions for demonstrating specific depression are injection of a small dose of parental lymphocytes and assay 7 days later. Pretreatment with cells from thymus and bone marrow is ineffective, as is pretreatment with purified B lymphocytes. The structures which stimulate the suppressed response of F1 hybrids are not present on parental B lymphocytes.

摘要

通过腘淋巴结肿大测定的F1杂种大鼠中的局部移植物抗宿主反应，可通过用亲代淋巴细胞预处理宿主而特异性地受到抑制。证明特异性抑制的条件是注射小剂量亲代淋巴细胞并在7天后进行测定。用来自胸腺和骨髓的细胞进行预处理无效，用纯化的B淋巴细胞进行预处理也无效。刺激F1杂种抑制反应的结构不存在于亲代B淋巴细胞上。

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