Lernmark Ake
Department of Clinical Sciences, Lund University/CRC, Skåne University Hospital SUS, Jan Waldenströms gata 35, SE-205 02, Malmö, Sweden,
Diabetologia. 2013 Sep 11. doi: 10.1007/s00125-013-3041-7.
Størling and colleagues hypothesise in this issue (Diabetologia DOI: 10.1007/s00125-013-3045-3 ) that post-translational modification (PTM) of autoantigens might create tissue-specific neo-epitopes that could trigger type 1 diabetes. Data on PTM of islet autoantigens are scarce and readers should not believe that the PTM hypothesis is supported by strong experimental evidence. The proposed genetic factors are many but their possible contribution is conjectural. There is a lack of a rational approach to test the PTM hypothesis at the different stages of type 1 diabetes. Research that carefully addresses each stage of the type 1 diabetes disease process is warranted to advance our understanding of autoimmune (type 1) diabetes.
斯特林及其同事在本期杂志（《糖尿病学》DOI：10.1007/s00125-013-3045-3）中提出假说，自身抗原的翻译后修饰（PTM）可能会产生组织特异性新表位，从而引发1型糖尿病。关于胰岛自身抗原翻译后修饰的数据很少，读者不应认为翻译后修饰假说有强有力的实验证据支持。提出的遗传因素众多，但其可能的作用只是推测。在1型糖尿病的不同阶段，缺乏一种合理的方法来检验翻译后修饰假说。有必要开展仔细研究1型糖尿病疾病过程各个阶段的研究，以增进我们对自身免疫性（1型）糖尿病的理解。
