Department of Breast and Endocrine Surgery, Kumamoto City Hospital, Kumamoto, 1-1-60 Kotoh, Kumamoto City, Kumamoto 862-8505, Japan.
Anticancer Res. 2013 Sep;33(9):3891-7.
A suitable cut-off value for p53 overexpression and its usefulness as a prognostic factor in luminal/HER2-negative breast cancer were evaluated.
A retrospective analysis of 1,987 patients with luminal/HER2-negative breast cancer who underwent surgery between 2001 and 2009 was performed.
p53 expression ≥50% was present in 9% of the patients. Moreover, these patients had significantly lower estrogen/progesterone receptor-positive rates, higher Ki-67 values, larger tumors, disease-positive nodes, higher nuclear grade, and shorter disease-free survival than patients with p53 expression <50% (p<0.0001). Therefore, status of p53-positive cells ≥50% was classified as p53 overexpression. These findings indicate that p53 overexpression is associated with unfavorable characteristics and prognosis.
The suitable cut-off value for p53 overexpression was determined to be 50%, and p53 overexpression appears to be a significant prognostic factor in patients with luminal/HER2-negative breast cancer.
评估 p53 过表达的合适截断值及其作为 luminal/HER2-阴性乳腺癌预后因素的作用。
对 2001 年至 2009 年间接受手术治疗的 1987 例 luminal/HER2-阴性乳腺癌患者进行回顾性分析。
9%的患者存在 p53 表达≥50%。此外，与 p53 表达<50%的患者相比，这些患者的雌激素/孕激素受体阳性率显著降低，Ki-67 值更高，肿瘤更大，阳性淋巴结更多，核分级更高，无病生存期更短（p<0.0001）。因此，将 p53 阳性细胞的比例≥50%定义为 p53 过表达。这些发现表明，p53 过表达与不良特征和预后相关。
确定了 p53 过表达的合适截断值为 50%，p53 过表达似乎是 luminal/HER2-阴性乳腺癌患者的一个重要预后因素。
