Department of Medicine and Cancer Center, Tufts Medical Center, 800 Washington Street Box 245, Boston, MA 02111, U.S.A.
Anticancer Res. 2013 Sep;33(9):4001-5.
Pancreatic neuroendocrine tumors (p-NETs) entail a vast array of tumors, which can vary from benign neoplastic growths to rapidly aggressive malignancies. Such is the case with ectopic adrenocorticotropic hormone (ACTH)-producing p-NETs. These tumors have been found to be quite aggressive and a challenge to treat, especially due to the occurrence of metastatic disease even after resection of the primary tumor. We discuss the case of a 44-year-old female who initially presented with vague, non-specific symptoms, in which a malignant p-NET was found to be the cause of her clinical presentation. Although resection of the pancreatic mass was performed, the patient presented again with metastatic disease to the liver.
胰腺神经内分泌肿瘤（p-NETs）包含了广泛的肿瘤，其从良性肿瘤生长到快速侵袭性恶性肿瘤不等。异位促肾上腺皮质激素（ACTH）产生的 p-NET 就是这种情况。这些肿瘤具有很强的侵袭性，治疗起来极具挑战性，尤其是由于即使在切除原发肿瘤后仍会发生转移疾病。我们讨论了一位 44 岁女性的病例，她最初表现出模糊、非特异性的症状，发现恶性 p-NET 是其临床表现的原因。尽管进行了胰腺肿块切除术，但患者再次出现肝转移疾病。
