左旋咪唑-硒补充剂对HIV/AIDS患者CD4增加效果的对比研究

Comparative study of levamisole-selenium supplementation effect on CD4 increase in HlV / AIDS patients.

作者信息

Mansouri Feizollah, Janbakhsh Alireza, Vaziri Siavash, Sayad Babak, Afsharian Mandana, Hosseinpor Farzaneh, Mahdavian Behzad

机构信息

Department of Infectious Diseases, Kermanshah University of Medical Sciences Kermanshah, Iran.

出版信息

Caspian J Intern Med. 2011 Spring;2(2):218-21.

PMID:24024019

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC3766938/

Abstract

BACKGROUND

Given to the abundant incidence of malnutrition in HIV(+) patients and its effect on progress of AIDS disease, several studies have recommended supplementation therapy (such as Selenium, Levamisole, Zinc).

METHODS

This clinical trial was prefunded on patient's with HIV + in Behavior Diseases Consulting Center, Kermanshah, Iran 2006-2007. One hundred-seventy eight out of all patients with CD4 1ess than 350 cell/mm(3) who did not receive antiretroviral drugs were in this study. They were divided into four groups: the first group received 200 micg selenium per day, the second group received levamisole 50 mg every other day, and third group received both two drugs. The fourth group was the control group. All four groups were studied for six months. Patients' baseline CD4 and other data were recorded in a form. CD4 was rechecked after six months and collected values were compared with basic values. CD4 changes were compared among all groups, either.

RESULTS

One hundred-seventy eight patients initiated treatment and 108 cooperated in the 6-month follow up assessment. Niuety-two (85%) were males and 15% were female. CD4 decreased in control group and Levamisole group during the study which was significant, but 13 units increase was seen in Selenium-Levamisole group. CD4 count decreased 36 units in Selenium group. Comparing CD4 count change among 4 study groups showed that only CD4 change between Selenium-Levamisole group and control group was significant.

CONCLUSION

Regarding to collected results, Selenium-Levamisole supplementation can be used as a supplementation therapy besides antiretroviral therapies.

摘要

背景

鉴于HIV阳性患者中营养不良的发生率很高及其对艾滋病病情进展的影响，多项研究推荐了补充疗法（如硒、左旋咪唑、锌）。

方法

这项临床试验于2006 - 2007年在伊朗克尔曼沙赫行为疾病咨询中心对HIV阳性患者进行预先资助。在所有未接受抗逆转录病毒药物且CD4细胞计数低于350个/mm³的患者中，有178人参与了本研究。他们被分为四组：第一组每天接受200微克硒，第二组每隔一天接受50毫克左旋咪唑，第三组同时接受这两种药物。第四组为对照组。所有四组均进行了六个月的研究。患者的基线CD4及其他数据以表格形式记录。六个月后复查CD4，并将收集到的值与基础值进行比较。同时也比较了所有组之间CD4的变化。

结果

178名患者开始治疗，108人参与了为期6个月的随访评估。92人（85%）为男性，15%为女性。在研究期间，对照组和左旋咪唑组的CD4下降，差异具有统计学意义，但硒 - 左旋咪唑组CD4增加了13个单位。硒组的CD4计数下降了36个单位。比较4个研究组之间的CD4计数变化表明，只有硒 - 左旋咪唑组与对照组之间的CD4变化具有显著性差异。