Gilbert J M, Weiss J S, Sattler A L, Koch J M
Department of Ophthalmology, Tufts-New England Medical Center, Boston.
Ophthalmology. 1990 Aug;97(8):1001-7. doi: 10.1016/s0161-6420(90)32473-9.
A prospective age- and sex-controlled study of seven anorexia nervosa patients and seven normal control patients was conducted to determine the ocular manifestations of anorexia nervosa. Slit-lamp examination of the anorexic patients demonstrated a high incidence (4/7) of multiple episcleral capillary aneurysms and subconjunctival hemorrhages. Two of seven anorexia nervosa patients had bilateral superficial punctate keratopathy. Anesthetized Schirmer tear testing demonstrated a significantly (P less than 0.005) reduced mean tear production in the anorexia nervosa group (11.3 mm) compared with the control group (22.4 mm). Masked interpretation of conjunctival impression cytology demonstrated moderate to severe conjunctival squamous metaplasia in the majority of the anorexia nervosa group (5/7) compared to normal conjunctival epithelium in the majority of the control group (5/7). Absence of nyctalopia, Bitot's spots, and xerosis, and lack of conjunctival goblet cell loss indicate that the anorexia nervosa group did not have vitamin A deficiency.
对7名神经性厌食症患者和7名正常对照患者进行了一项前瞻性年龄和性别对照研究，以确定神经性厌食症的眼部表现。对厌食症患者进行裂隙灯检查发现，多发性巩膜表层毛细血管瘤和结膜下出血的发生率很高（4/7）。7名神经性厌食症患者中有2名患有双侧浅层点状角膜病变。麻醉状态下的泪液分泌试验显示，与对照组（22.4毫米）相比，神经性厌食症组（11.3毫米）的平均泪液分泌量显著减少（P<0.005）。对结膜印片细胞学的盲法解读显示，大多数神经性厌食症组患者（5/7）出现中度至重度结膜鳞状化生，而大多数对照组患者（5/7）为正常结膜上皮。无夜盲、毕脱斑和干眼症，且结膜杯状细胞未缺失，表明神经性厌食症组不存在维生素A缺乏。
