采用卡莫司汀、依托泊苷、阿糖胞苷、美法仑加氨磷汀进行预处理方案用于门诊自体干细胞移植：97例淋巴瘤患者的可行性及结果 - Suppr

Conditioning regimen with BCNU, etoposide, cytarabine and melphalan plus amifostine for outpatient autologous stem cell transplant: feasibility and outcome in 97 patients with lymphoma.

作者信息

Scortechini Ilaria, Montanari Mauro, Mancini Giorgia, Inglese Elena, Calandrelli Monica, Chiarucci Martina, Offidani Massimo, Capelli Debora, Gini Guido, Poloni Antonella, Mancini Stefania, Raggetti Gianmario, Leoni Pietro, Olivieri Attilio

机构信息

Department of Hematology, Ospedali Riuniti di Ancona , Ancona , Italy.

出版信息

Leuk Lymphoma. 2014 Jul;55(7):1657-60. doi: 10.3109/10428194.2013.842989. Epub 2013 Nov 1.

DOI:10.3109/10428194.2013.842989

PMID:24024474

Abstract

摘要

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Conditioning regimen with BCNU, etoposide, cytarabine and melphalan plus amifostine for outpatient autologous stem cell transplant: feasibility and outcome in 97 patients with lymphoma.采用卡莫司汀、依托泊苷、阿糖胞苷、美法仑加氨磷汀进行预处理方案用于门诊自体干细胞移植：97例淋巴瘤患者的可行性及结果

Leuk Lymphoma. 2014 Jul;55(7):1657-60. doi: 10.3109/10428194.2013.842989. Epub 2013 Nov 1.

Phase II Study of Propylene Glycol-Free Melphalan Combined with Carmustine, Etoposide, and Cytarabine for Myeloablative Conditioning in Lymphoma Patients Undergoing Autologous Stem Cell Transplantation.不含丙二醇的美法仑联合卡莫司汀、依托泊苷和阿糖胞苷用于淋巴瘤患者自体干细胞移植清髓预处理的II期研究。

Biol Blood Marrow Transplant. 2016 Dec;22(12):2155-2158. doi: 10.1016/j.bbmt.2016.08.026. Epub 2016 Aug 26.

Dexamethasone, carmustine, etoposide, cytarabine, and melphalan (dexa-BEAM) followed by high-dose chemotherapy and stem cell rescue--a highly effective regimen for patients with refractory or relapsed indolent lymphoma.地塞米松、卡莫司汀、依托泊苷、阿糖胞苷和美法仑（地塞米松-卡莫司汀-依托泊苷-阿糖胞苷-美法仑方案），随后进行大剂量化疗和干细胞救援——这是一种针对难治性或复发性惰性淋巴瘤患者的高效治疗方案。

Leuk Lymphoma. 2000 Mar;37(1-2):115-23. doi: 10.3109/10428190009057634.

Phase I study for poor-prognosis lymphoma: augmentation of the "BEAM" regimen with escalating dose melphalan using amifostine cytoprotection and autologous hematopoietic stem cell transplantation--a preliminary report.预后不良淋巴瘤的I期研究：使用氨磷汀进行细胞保护并采用递增剂量美法仑强化“BEAM”方案及自体造血干细胞移植——初步报告

Semin Oncol. 2004 Dec;31(6 Suppl 18):59-61. doi: 10.1053/j.seminoncol.2004.12.014.

Fotemustine plus etoposide, cytarabine and melphalan (FEAM) as a new conditioning regimen for lymphoma patients undergoing auto-SCT: a multicenter feasibility study.福莫司汀联合依托泊苷、阿糖胞苷和马法兰（FEAM）作为淋巴瘤患者自体外周血干细胞移植预处理方案的多中心可行性研究。

Bone Marrow Transplant. 2010 Jul;45(7):1147-53. doi: 10.1038/bmt.2009.318. Epub 2009 Nov 9.

Effect of the dose per body weight of conditioning chemotherapy on severity of mucositis and risk of relapse after autologous haematopoietic stem cell transplantation in relapsed diffuse large B cell lymphoma.复发弥漫性大B细胞淋巴瘤自体造血干细胞移植中，预处理化疗的每体重剂量对粘膜炎严重程度及复发风险的影响。

Br J Haematol. 2008 Oct;143(2):268-73. doi: 10.1111/j.1365-2141.2008.07342.x. Epub 2008 Aug 10.

Retrospective evaluation of the MEAM regimen as a conditioning regimen before autologous peripheral blood stem cell transplantation for lymphoma in two centers with different dosing schedules of melphalan.在两个美法仑给药方案不同的中心，对MEAM方案作为淋巴瘤自体外周血干细胞移植前预处理方案进行回顾性评估。

Ann Hematol. 2016 Sep;95(9):1513-9. doi: 10.1007/s00277-016-2740-9. Epub 2016 Jul 1.

A Phase I trial: dose escalation of melphalan in the "BEAM" regimen using amifostine cytoprotection.一项 I 期临床试验：使用氨磷汀细胞保护剂，在“BEAM”方案中递增美法仑剂量。

Biol Blood Marrow Transplant. 2011 Jul;17(7):1033-42. doi: 10.1016/j.bbmt.2010.11.003. Epub 2010 Nov 11.

Carmustine, etoposide, cytarabine and melphalan as a preparative regimen for allogeneic transplantation for high-risk malignant lymphoma.卡莫司汀、依托泊苷、阿糖胞苷和美法仑作为高危恶性淋巴瘤异基因移植的预处理方案。

Ann Oncol. 1999 May;10(5):527-32. doi: 10.1093/oxfordjournals.annonc.a010369.

Autologous stem cell transplantation for follicular lymphoma: no benefit for early transplant?自体干细胞移植治疗滤泡性淋巴瘤：早期移植无益处？

Ann Hematol. 2001 Jul;80(7):398-405. doi: 10.1007/s002770100321.

引用本文的文献

LEAM vs. BEAM vs. CLV Conditioning Regimen for Autologous Stem Cell Transplantation in Malignant Lymphomas. Retrospective Comparison of Toxicity and Efficacy on 222 Patients in the First 100 Days After Transplant, On Behalf of the Romanian Society for Bone Marrow Transplantation.用于恶性淋巴瘤自体干细胞移植的LEAM方案、BEAM方案与CLV预处理方案对比：代表罗马尼亚骨髓移植学会对222例患者移植后前100天毒性和疗效的回顾性比较

Front Oncol. 2019 Sep 10;9:892. doi: 10.3389/fonc.2019.00892. eCollection 2019.

Outpatient administration of BEAM conditioning prior to autologous stem cell transplantation for lymphoma is safe, feasible, and cost-effective.对于淋巴瘤患者，在自体干细胞移植前进行门诊BEAM预处理是安全、可行且具有成本效益的。

Cancer Med. 2016 Nov;5(11):3059-3067. doi: 10.1002/cam4.879. Epub 2016 Oct 3.

Italian consensus conference for the outpatient autologous stem cell transplantation management in multiple myeloma.意大利多发性骨髓瘤门诊自体干细胞移植管理共识会议

Bone Marrow Transplant. 2016 Aug;51(8):1032-40. doi: 10.1038/bmt.2016.79. Epub 2016 Apr 4.

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Conditioning regimen with BCNU, etoposide, cytarabine and melphalan plus amifostine for outpatient autologous stem cell transplant: feasibility and outcome in 97 patients with lymphoma.

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