Parashette Kalyan Ray, Zeytinoglu Meltem, Kernek Kevin, Molleston Jean P, Subbarao Girish
Indiana University School of Medicine, James Whitcomb Riley Hospital for Children, Pediatric Gastroenterology, Hepatology and Nutrition, Indianapolis, IN, USA.
Pediatr Transplant. 2013 Dec;17(8):737-43. doi: 10.1111/petr.12143. Epub 2013 Sep 12.
Immunosuppression during the post-transplantation period has led to dramatic outcome improvements in PLTR patients. There have been reports describing the development of food allergies and an increased predilection for development of EGI in PLTR. We aimed to identify the clinical, endoscopic and histologic features of EGI in PLTR patients. In this retrospective case series we analyzed medical record of all PLTR who underwent EGD and/or colonoscopy at our institution from 2000 to 2006. From 2000 to 2006, 32 PLTR patients underwent endoscopic evaluation. Seventeen (53%) of 32 patients were diagnosed with EGI. Endoscopic abnormalities were seen in the esophagus, stomach, and small intestine in 11 (65%), 11 (65%), and four (24%) patients, respectively. Eosinophilic inflammation was seen in the esophagus, stomach, and small intestine in 13 (76%), 10 (59%), and five (29%) patients, respectively. Nine of 17 patients underwent colonoscopy and endoscopic abnormalities were seen in four (44%) patients. Five patients (56%) had eosinophilic inflammation. In conclusion, we have characterized the clinical, endoscopic, and histologic features of EGI. Histologic and endoscopic examination reveals that, when present, EGI is often found at multiple segments along the gastrointestinal tract.
移植后阶段的免疫抑制使实体器官移植受者（PLTR）的治疗效果有了显著改善。有报告描述了PLTR中食物过敏的发生情况以及胃肠道感染（EGI）易感性的增加。我们旨在确定PLTR患者EGI的临床、内镜和组织学特征。在这个回顾性病例系列中，我们分析了2000年至2006年在我们机构接受上消化道内镜检查（EGD）和/或结肠镜检查的所有PLTR的病历。2000年至2006年，32例PLTR患者接受了内镜评估。32例患者中有17例（53%）被诊断为EGI。分别有11例（65%）、11例（65%）和4例（24%）患者的食管、胃和小肠出现内镜异常。分别有13例（76%）、10例（59%）和5例（29%）患者的食管、胃和小肠出现嗜酸性炎症。17例患者中有9例接受了结肠镜检查，4例（44%）患者出现内镜异常。5例患者（56%）有嗜酸性炎症。总之，我们已经描述了EGI的临床、内镜和组织学特征。组织学和内镜检查显示，EGI一旦出现，往往在胃肠道的多个节段被发现。
