Swiss Light Source, Paul Scherrer Institut, 5232 Villigen, Switzerland.
Phys Med Biol. 2013 Oct 7;58(19):6815-26. doi: 10.1088/0031-9155/58/19/6815. Epub 2013 Sep 11.
X-ray grating interferometry is a promising tool for medical imaging because of its capability of providing additional and complementary information to conventional absorption-based methods. This technology can simultaneously measure absorption, differential phase and small-angle scattering signals from the sample, significantly improving the diagnostic content. In this work, we present a method which uses the image (dubbed the R image) obtained by taking the ratio of the absorption and small-angle scattering signals to gain quantitative insight from a radiographic x-ray projection. We demonstrate that with the help of the R image we can successfully distinguish among different (light-Z) plastic materials, which are usually used to mimic soft tissues. Two potential applications in medical imaging, such as quantitative x-ray radiography and volumetric breast density estimation, are demonstrated.
X 射线光栅干涉测量是一种很有前途的医学成像工具，因为它能够提供传统基于吸收的方法的额外和补充信息。这项技术可以从样品中同时测量吸收、差分相位和小角度散射信号，显著提高诊断内容。在这项工作中，我们提出了一种方法，该方法使用通过吸收和小角度散射信号的比值获得的图像（称为 R 图像），从射线照相 X 射线投影中获得定量的洞察力。我们证明，借助 R 图像，我们可以成功地区分通常用于模拟软组织的不同（轻 Z）塑料材料。展示了医学成像中的两个潜在应用，如定量 X 射线射线照相和乳房体积密度估计。
