Hallbäck D A, Eriksson M, Sjöqvist A
Dept. of Physiology, University of Gothenburg, Sweden.
Scand J Gastroenterol. 1990 Aug;25(8):859-64. doi: 10.3109/00365529008999226.
The hypothesis tested in this study is whether a potential harmful substance such as ethanol causes secretion in the small intestine and, if so, whether the secretion is mediated via intestinal nerve reflexes or a direct effect on the epithelium. The jejunum of anaesthetized Sprague-Dawley rats was perfused in vivo with a modified Krebs-Henseleit solution. Three per cent ethanol had no significant effect, whereas 8% ethanol in the perfusate elicited a net secretion of fluid and sodium in the intestine. This secretion was reversed by ganglionic blockade with hexamethonium (10 mg/kg intravenously). The ethanol absorption from the perfusate, on the other hand, was not affected by the ganglionic blockade. We concluded that ethanol dose-dependently caused a nerve-mediated secretion of sodium and fluid in the rat small intestine. Ethanol was probably absorbed by diffusion.
本研究中所检验的假设是，像乙醇这样的潜在有害物质是否会导致小肠分泌，如果会，那么这种分泌是通过肠神经反射介导的，还是对上皮细胞的直接作用。对麻醉的Sprague-Dawley大鼠的空肠进行体内灌注改良的克雷布斯-亨泽莱特溶液。3%的乙醇没有显著影响，而灌注液中8%的乙醇引起小肠中液体和钠的净分泌。用六甲铵（静脉注射10mg/kg）进行神经节阻断可逆转这种分泌。另一方面，灌注液中乙醇的吸收不受神经节阻断的影响。我们得出结论，乙醇剂量依赖性地导致大鼠小肠中神经介导的钠和液体分泌。乙醇可能通过扩散被吸收。
